[BBF Standards] functional composition of BioBrick parts?

[Mackenzie Cowell]

Hello Everyone,

I seeded the BBF wiki page at
http://openwetware.org/wiki/The_BioBricks_Foundation:Standards/Technicalwith
some of the main points of the recent discussion.

You can also navigate to a "dewikified" version of the page from the BBF
homepage at http://biobricks.org/, or directly via
http://bbf.openwetware.org/Standards/Technical.html.

And here is a BioBrick part data model question: should there be a
one-to-one relationship between a part 's functional definition and its
sequence?  What if you introduce a silent mutation into a BioBrick - is
there a "different sequence, different part" doctrine, even if the two are
functionally equivalent?  Additionally, how are codon-optimized sequences
for the same function related to one another?  Families of tuned promoters?
Is this a source code vs. compiled code issue?

-Mac

On Jan 31, 2008 10:01 PM, Bryan Bishop <kanzure at gmail.com> wrote:

> On Thursday 31 January 2008, "Julius B. Lucks" wrote:
> > It sounds like there needs to be an annotation system in place that
> > would allow compatibility evidence to be labeled as experimentally or
> >   computationally generated (or both).  We might even consider the
> > possibility of digitally signing the annotations to associate
> > experiments or calculations with known labs.  The preliminary
> > question would be whether or not the annotations would be a part of
> > the main parts ontology, or would it be a separate ontology itself.
>
> I certainly see the need to be able to reference other sub-ontologies
> related to understanding the experimental methods for testing the
> brick, or the specifications for the computational evidence etc.
>
> - Bryan
> ________________________________________
> Bryan Bishop
> http://heybryan.org/
>
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-- 
Mac Cowell
iGEM Coordinator
igem.org
231.313.9062
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