[BBF Standards] Input/output

[Drew Endy]

Hi Bryan,

Check out the ideas of PoPS (polymerase per second).  It's a  
placeholder common signal carrier that let's you exchange molecular  
signals carried via different types of molecules using a common signal  
carrier based on the rate of gene expression.  There are several  
limitations with PoPS.  One obvious limitation is that PoPS is only  
relevant for engineered biological devices that route some action /  
activity through gene expression.

Here are two references to check out.  Chapter 2 and 3 of this comic  
strip:
http://mit.edu/endy/www/scraps/comic/AiSB.vol1.pdf

Also, please see the datasheet for BBa_F2620:
http://parts.mit.edu/registry/index.php/Part:BBa_F2620

Drew

On Feb 11, 2008, at 7:42 AM, Bryan Bishop wrote:

> I was talking with a Slashdot user yesterday who reminded me one of  
> the
> important points that I have been missing when it comes to biobricks,
> namely the goal of data i/o, and so I have briefly outlined an idea  
> for
> a standard and am hoping the list can add a few thoughts to this:
>
> Radioprotein:
> * Protein antenna
> * For starters - chemical substrate to activate enzyme.
> ** Later: integral protein / receptor site. Ex: catch 1% of dopamine.
> * Evolutionary experiments with relevant selector?
> ** those colonies which are able to transmit are triangulated are  
> given
> food by a mechanical arm in a few tanks?
> A first project: radio-controlled bacterial movement.
>
> The problem is that there is never going to be just _one_ radioprotien
> and there's no way that we are going to be hacking together a single
> bit transmission system. Instead, we are going to be getting tons of
> bits and bytes out of bacterial colonies at the same time, in  
> parallel,
> and need a way to record this information. Unfortunately, from what
> little I know of protein expression, this seems to mean that it will
> always involve molecular gradients for comm, and we are not all that
> good at working with molecular gradients. Perhaps we have to study the
> genetics of the cellular messenging systems? I hope it's a template.
>
> - Bryan
> ________________________________________
> Bryan Bishop
> http://heybryan.org/
>
> _______________________________________________
> Standards mailing list
> Standards at biobricks.org
> http://biobricks.org/mailman/listinfo/standards_biobricks.org